Cabergoline, 1mg Bottle of 10 tablets

Indication:

For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.

Mechanism of Action:

The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentrations and blocks IP3-dependent release of Ca2+ from intracellular stores. Decreases in intracellular calcium levels may also be brought about via inhibition of calcium influx through voltage-gated calcium channels, rather than via inhibition of adenylyl cyclase. Additionally, receptor activation blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. Inhibition of MAPK appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. Dopamine-stimulated growth hormone release from the pituitary gland is mediated by a decrease in intracellular calcium influx through voltage-gated calcium channels rather than via adenylyl cyclase inhibition. Stimulation of dopamine D2 receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders. Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. Receptor-binding studies indicate that cabergoline has low affinity for dopamine D1, 1,- and 2- adrenergic, and 5-HT1- and 5-HT2-serotonin receptors.

Side Effects:

Nausea, vomiting, stomach upset, constipation, dizziness, lightheadedness, or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Precautions:

Before taking Dostinex, tell your doctor or pharmacist if you are allergic to it; or to other ergot medications (such as ergotamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Also, this drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Drug interactions:

Some products that may interact with this drug include: lorcaserin, metoclopramide, prochlorperazine.

Dosage:

The suggested dosage can vary based on the specific condition being treated, but for hyperprolactinemia, the usual starting dose is often 0.5 mg to 1 mg taken once or twice weekly. Dosage may be adjusted based on the patient’s response and tolerance, with the maximum recommended dose being up to 3 mg per week. It is important for patients to follow their healthcare provider’s specific recommendations regarding dosing and to have regular monitoring to assess efficacy and minimize potential side effects.

Storage:

Store in a dark, dry place, at room temperature. Do not refrigerate. Keep out of reach of children.

This medicine must be given only by medical prescription!

Regulatory Compliance Statements:

• This product complies with relevant
  regulatory guidelines.
• Certified under Good Manufacturing Practices (GMP).

Safety Information:

• Overdose Instructions: In case of overdose, seek immediate medical attention.
• Adverse Reactions: Report any adverse reactions to your healthcare provider.

Q: Why are there spots or color variations on the tablets?

A:This is a natural occurrence due to the high-quality raw materials we use and is a sign of our minimal processing. Please rest assured that every batch is rigorously lab-tested for potency, purity, and sterility. These natural variations do not affect the product’s safety or effectiveness and are your guarantee of a premium, unadulterated product.