Letrozole, 2.5mg (50 tabs)

Mechanism of medicine action:

Letrozole is a non-steroidal type II aromatase inhibitor. It blocks the active site, and therefore the electron transfer chain of CYP19A1. This competitive inhibition prevents the conversion of androgens to estrogen. This action leads to a reduction in uterine weight and elevated leuteinizing hormone. In postmenopausal women, the action of aromatase is responsible for the majority of estrogen production. With reduced availability of estrogen, estrogen-dependant tumors regress. Third generation aromatase inhibitors do not significantly affect cortisol, aldosterone, and thyroxine levels.

Indications:

Letrozole is indicated to treat postmenopausal women with hormone receptor (HR) positive early breast cancer, postmenopausal women with early breast cancer who have periviously been treated with tamoxifen, and postmenopausal women with HR+ or unknown advanced breast cancer. Letrozole, given with ribociclib, is indicated to treat pre, peri, and postmenopausal women with HR+ and human epidermal growth factor 2 (HER2) negative advanced or metastatic breast cancer.

Contraindications:

Letrozole should not be administered to individuals with known hypersensitivity to the drug or any of its components. It is also contraindicated in premenopausal women, as its mechanism of action is ineffective in this population, and in those who are pregnant or breastfeeding due to potential harm to the fetus or infant.

Precautions:

When prescribed Letrozole, caution is advised in patients with a history of cardiovascular disease or osteoporosis, as the drug may impact bone density over time. Regular monitoring of bone health and cardiovascular status is recommended for patients undergoing treatment.

Drug interactions:

Letrozole can interact with other medications that are metabolized by the liver’s cytochrome P450 system, particularly CYP2A6 and CYP3A4. Notable interactions may occur with drugs such as tamoxifen, estrogen supplements, and some antifungal or antibacterial agents. A complete medication review should be performed prior to prescribing Letrozole to avoid adverse interactions.

Dosage:

The typical starting dosage for adults is one 2.5 mg tablet taken orally once daily. The dosage may be adjusted based on clinical response and the prescribing physician’s assessment. Treatment duration varies and should be determined by the healthcare provider based on the patient’s specific condition.

Storage:

Store in a dark, dry place, at room temperature. Keep out of reach of children.

Regulatory Compliance Statements:

This product complies with relevant regulatory guidelines. Certified under Good Manufacturing Practices (GMP).

Safety Information:

• Overdose Instructions: In case of overdose, seek immediate medical attention.
• Adverse Reactions: Report any adverse reactions to your healthcare provider.

Q: Why are there spots or color variations on the tablets?

A:This is a natural occurrence due to the high-quality raw materials we use and is a sign of our minimal processing. Please rest assured that every batch is rigorously lab-tested for potency, purity, and sterility. These natural variations do not affect the product’s safety or effectiveness and are your guarantee of a premium, unadulterated product.